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Natural OXM peptide has both neuroprotective and neurotrophic effects against oxidative stress and glutamate toxicity in cultured primary cortical neurons of rat and SH-SY5Y cells, two cellular models that are broad applied to evaluating neuroprotective and neurotrophic effects of experimental therapeutics in the development of neuroprotective agents (127)

second, it binds to cellular GST/GSH, depleting its intracellular content to weaken the efflux of chemotherapy drugs in tumor cells